Budget vs premium
Refills vs He & She MD: Which Costs Less Over 12 Months? (2026)
Compare Refills and He & She MD on real cost over 12 months, medication type, price stability and support. Independent 2026 analysis, no first-month gimmicks.
Published · Pricing as published in our provider dataset, synced · Editorial scores 7.7 and 7.0 out of 10
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Two platforms, one drug class, and a difference in annual cost most people do not notice until month four. That is the Refills versus He & She MD question.
He & She MD costs 93% more per month than Refills once promotional pricing is out of the picture ($191/mo against $99/mo). Over a year that gap compounds into real money, and the question is what it buys.
What follows is a like-for-like read of both programs: entry pricing, maintenance pricing, formulary, support model and the terms attached to each. No number here is inferred; if a provider does not publish it, the table says so.
The short answer
- Lowest 12-month cost
- Refills — $1,188 against $1,980 at He & She MD, on each provider's own best published pricing.
- Most predictable bill
- Refills — Flat rate at every dose, so titration does not change what you are charged.
- Least friction to get going
- He & She MD — 2-3 minute intake with no payment required to check eligibility, then free expedited shipping with no upcharges.
- Most support included
- He & She MD — Coaching app with 1:1 clinician messaging and progress tracking, no extra charge.
Refills vs He & She MD: the specification
Every figure below is the provider's own published number. The blank spaces are theirs, not ours.
| Refills | He & She MD | |
|---|---|---|
| Advertised price | GLP-1 from $99/mo, about $5 a day | Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo |
| Rate after promotions | $99/mo | $191/mo |
| Pricing structure | Flat rate at every dose | Introductory term, then renewal at a higher rate |
| Medication | Compounded semaglutide and GIP+GLP-1 dual agonist | Compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection |
| State coverage | Availability varies by state | Not published |
| How fast you start | 3-minute approval quiz | 2-3 minute intake with no payment required to check eligibility |
| Membership fee | None | None |
| Payment options | Card only, no financing published | Card only, no financing published |
| Patient reviews | 7,400 | 4,180 |
| eRxDoctor score | 7.7/10 | 7.0/10 |
The real cost: six months and twelve
Trial data runs to 68 and 72 weeks; the pricing people compare runs to 30 days. These are the totals — six months and twelve — using each provider's own published rates and best available plan.
| Refills | He & She MD | |
|---|---|---|
| First month | $99 | $139 |
| Months 2 onward | $99/mo | $191/mo |
| 6-month total | $594 | $834 |
| 12-month total | $1,188 | $1,980 |
| Best published plan | No multi-month discount published | No multi-month discount published |
The twelve-month spread is $792. That is the number to hold He & She MD against: it has to justify roughly $66 extra every month.
Price escalation to plan for: He & She MD moves from $139 to $191, a 37% increase. Set a calendar reminder for the month it changes.
What the price difference actually buys
Before treating the cheaper option as the obvious one, it is worth naming what the more expensive one includes — at He & She MD that is coaching app with 1:1 clinician messaging and progress tracking, no extra charge, plus free expedited shipping with no upcharges.
Refills's answer is $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing. What it does not carry: clinicians come from partner networks and availability varies by state.
For a patient who has taken a GLP-1 before, knows how they titrate and needs a reliable monthly refill, the cheaper program is usually the correct one and the premium is a donation. For a first prescription, the calculus changes.
How Refills works
Refills offers personalized compounded GLP-1 from $99/month (~$5/day) with flat pricing, the same price at every dosage, plus free discreet shipping, 24/7 health concierge support, and no membership or app fees. Against He & She MD, that puts it in the position of the cheaper option.
From signup to first shipment: 3-minute approval quiz, then free, fast and discreet shipping on every order. Billing follows a flat rate at every dose structure.
What continues after the first shipment: free 24/7 health concierge. Formulary: compounded semaglutide and GIP+GLP-1 dual agonist.
Refills pros
- Personalized GLP-1 from $99/mo (~$5/day); GIP+GLP-1 dual agonist available
- Flat pricing, the same low price at every dosage, no titration upcharges
- No monthly memberships or app fees
- 40% off new patient special offers
Refills cons
- Compounded medication, not an FDA-approved branded product
- Clinicians come from partner telehealth networks (Beluga, Bask, Wasef Health)
- Availability varies by state
Read next to He & She MD, the weak point: clinicians come from partner networks and availability varies by state.
Inside the He & She MD program
He & She MD bundles compounded GLP-1 medication with a coaching app that carries 1:1 clinician messaging, GLP-1-specific guidance and progress tracking. Semaglutide injections start at $139/month, oral semaglutide and tirzepatide at $199/month, each a six-month introductory rate. Free expedited shipping, no membership fee, no insurance required. What it is really selling here is three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO.
You start with 2-3 minute intake with no payment required to check eligibility; medication arrives via free expedited shipping with no upcharges. The price behaves as introductory term, then renewal at a higher rate.
Coaching app with 1:1 clinician messaging and progress tracking, no extra charge. The formulary covers compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection.
He & She MD pros
- Free expedited shipping on every order, with no shipping upcharges
- No membership fee stacked on top of the medication price
- Fast 2-3 minute intake with no payment required to check eligibility
- Coaching app, 1:1 clinician messaging and progress tracking included at no extra cost
He & She MD cons
- Pricing is structured as six-month terms, not true month-to-month
- Headline prices are 6-month intro rates that renew 30-45% higher
- The 15-25 lbs in 12 weeks figure is self-reported retrospective data, not trial data
The reservation worth holding, particularly next to Refills: the headline rates are six-month terms that renew 30-45% higher.
Who each program is actually built for
Choose Refills if:
- the level of clinical contact suits you: free 24/7 health concierge
- you want to start on their timeline: 3-minute approval quiz
- delivery works the way you want it to: free, fast and discreet shipping on every order
- the monthly rate is the constraint — $99/mo against $191/mo
Choose He & She MD if:
- the level of clinical contact suits you: coaching app with 1:1 clinician messaging and progress tracking, no extra charge
- you want to start on their timeline: 2-3 minute intake with no payment required to check eligibility
- you want coaching app with 1:1 clinician messaging and progress tracking, no extra charge rather than a prescription alone
- what it leads on is worth paying for in your case: three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO
What each one gives up
On price. The monthly gap is 93% in Refills's favor. Whether that is a saving or a false economy turns on one thing: clinicians come from partner networks and availability varies by state.
On commitment. Neither publishes a multi-month discount, so both are month-to-month decisions and neither asks you to prepay for a response you have not had yet. Neither publishes financing options, so plan for the full amount each month.
On predictability. The pricing structures differ (flat rate at every dose versus introductory term, then renewal at a higher rate), and structure, not headline rate, determines the twelve-month bill.
On access. Refills advertises 3-minute approval quiz and free, fast and discreet shipping on every order; He & She MD advertises 2-3 minute intake with no payment required to check eligibility and free expedited shipping with no upcharges. Coverage differs too — availability varies by state against not published — which decides the question before price does if you are in a restricted state.
What the evidence actually says
The efficacy data people cite when comparing these platforms is not platform data. It comes from trials of the underlying medication, and it applies to both.
NIDDK frames medication as one component of obesity treatment rather than a replacement for the rest of it, per NIH, NIDDK.
SURMOUNT-4 found that continuing tirzepatide maintained and extended weight reduction, while withdrawing it led to substantial regain, per JAMA, SURMOUNT-4.
Which is to say: the medication decision belongs with a clinician, and the platform decision belongs with a spreadsheet.
Refills vs He & She MD: common questions
Does the price go up as my dose increases?
At Refills, no — $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing. At He & She MD, the published structure is introductory term, then renewal at a higher rate, moving from $139 to $191. Since GLP-1 doses escalate over the first months, that difference is worth more than most feature comparisons.
Which costs less over a year, Refills or He & She MD?
Refills, at roughly $1,188 for twelve months against $1,980 at He & She MD, using each provider's own best published pricing. Those totals cover medication and program fees as published; they exclude anything a provider bills separately, and they assume you stay on the same plan for the full year.
Do Refills or He & She MD take insurance?
Both run on a direct-pay basis: you pay the platform and it does not bill your insurer. Neither publishes HSA/FSA acceptance, so budget the full amount as out-of-pocket spending.
Which has more patient reviews, Refills or He & She MD?
Refills, with 7,400 against 4,180. Ratings across this market cluster tightly, so volume is the more useful signal: it indicates how much operational load the platform has already absorbed, not how good the medication is.
Is coaching included with Refills or He & She MD?
He & She MD includes coaching app with 1:1 clinician messaging and progress tracking, no extra charge in the monthly price. Refills provides free 24/7 health concierge, without a separate coaching program. If medication alone has failed you before, the bundled version is the one to price properly rather than the one to cut.
How fast can I start with Refills compared with He & She MD?
Refills advertises 3-minute approval quiz, with free, fast and discreet shipping on every order. He & She MD advertises 2-3 minute intake with no payment required to check eligibility, with free expedited shipping with no upcharges. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
The verdict
Refills is the cheaper year by $792, and for a straightforward course of treatment that settles it.
He & She MD earns the difference in one situation: when three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO is something you will genuinely use. If you cannot say that out loud, take the cheaper program.
Both platforms are legitimate routes to a GLP-1 prescription. The decision is commercial, and it should be made with the twelve-month figure in front of you rather than the first-month one.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Refills or He & She MD, and does not sell treatment. Read our ranking methodology.