Budget vs premium
Enhance MD vs Refills: Which Costs Less Over 12 Months? (2026)
Enhance MD or Refills? Side-by-side 2026 pricing, medication and service comparison, extended to six and twelve-month totals.
Published · Pricing as published in our provider dataset, synced · Editorial scores 8.4 and 7.7 out of 10
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Put Enhance MD and Refills side by side and the marketing reads almost identically. The programs underneath do not.
Refills costs 2.0x more per month than Enhance MD once promotional pricing is out of the picture ($99/mo against $49/mo). Over a year that gap compounds into real money, and the question is what it buys.
The comparison below starts from published pricing, converts it into annual cost, and then asks what the more expensive side is delivering for the difference. Every figure traces back to the provider's own published material, and the missing ones stay missing.
The short answer
- Lowest ongoing rate
- Enhance MD — $49/mo against $99/mo, though only one of the two publishes enough to total a full year.
- Most predictable bill
- Enhance MD — Flat rate at every dose, so titration does not change what you are charged.
- Least friction to get going
- Enhance MD — Online intake, then home delivery.
- Easiest to pay for
- Enhance MD — Neither publishes financing; both expect the full amount monthly.
Side-by-side comparison
The rows below are the ones that differ enough between these two to be worth your attention.
| Enhance MD | Refills | |
|---|---|---|
| Advertised price | Semaglutide from $49, tirzepatide from $99, first month | GLP-1 from $99/mo, about $5 a day |
| Rate after promotions | $49/mo | $99/mo |
| Pricing structure | Flat rate at every dose | Flat rate at every dose |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide and GIP+GLP-1 dual agonist |
| Payment options | Card only, no financing published | Card only, no financing published |
| Membership fee | Not stated | None |
| How fast you start | Online intake | 3-minute approval quiz |
| State coverage | Not published | Availability varies by state |
| Patient reviews | 10,482 | 7,400 |
| eRxDoctor score | 8.4/10 | 7.7/10 |
What Enhance MD and Refills actually cost over a year
Comparing entry prices across these two would be actively misleading, because they escalate differently. Below, both are carried out to six and twelve months so the comparison holds at the point it matters.
| Enhance MD | Refills | |
|---|---|---|
| First month | $49 | $99 |
| Months 2 onward | Not published | $99/mo |
| 6-month total | Not computable | $594 |
| 12-month total | Not computable | $1,188 |
| Best published plan | No multi-month discount published | No multi-month discount published |
A like-for-like annual total is not available for Enhance MD: the ongoing flat rate is higher than the $49 introductory month and is not prominently published before intake. Treat any comparison that quotes one as an estimate someone else has made for you.
Is Refills worth the premium?
Before treating the cheaper option as the obvious one, it is worth naming what the more expensive one includes — at Refills that is free 24/7 health concierge, plus free, fast and discreet shipping on every order.
Enhance MD counters with the lowest first month anywhere on this list, on both compounds, and the thing it asks you to accept in return: what you pay in month two is the number that is missing.
For a patient who has taken a GLP-1 before, knows how they titrate and needs a reliable monthly refill, the cheaper program is usually the correct one and the premium is a donation. For a first prescription, the calculus changes.
Enhance MD in detail
Enhance MD offers semaglutide from $49 and tirzepatide from $99 for your first month, with flat-rate pricing that stays the same at every dose, no fee escalation. What it is really selling here is the lowest first month anywhere on this list, on both compounds.
Getting started means online intake, after which home delivery. Pricing runs on a flat rate at every dose basis, partly published.
On the clinical side, 10,000+ patients treated, prescribing compounded semaglutide and compounded tirzepatide.
Enhance MD pros
- No hidden fees at higher doses
- Cheapest first month for both compounds, semaglutide from $49 and tirzepatide from $99
- Flat-rate pricing: the same price at every dose, with no fee escalation during titration
- Both semaglutide and tirzepatide available on one platform
Enhance MD cons
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
- The $49/$99 rates are first-month introductory prices; ongoing flat rate is higher
- Ongoing flat-rate pricing not always prominently published before intake
Against Refills specifically, the trade you are making: what you pay in month two is the number that is missing.
Refills: what you are buying
Refills offers personalized compounded GLP-1 from $99/month (~$5/day) with flat pricing, the same price at every dosage, plus free discreet shipping, 24/7 health concierge support, and no membership or app fees. In this pairing, its distinguishing feature is $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing.
Intake is 3-minute approval quiz. Fulfillment is free, fast and discreet shipping on every order. The commercial terms are flat rate at every dose, published upfront.
Behind the prescription sits free 24/7 health concierge. Available medication: compounded semaglutide and GIP+GLP-1 dual agonist.
Refills pros
- Personalized GLP-1 from $99/mo (~$5/day); GIP+GLP-1 dual agonist available
- Flat pricing, the same low price at every dosage, no titration upcharges
- No monthly memberships or app fees
- 40% off new patient special offers
Refills cons
- Compounded medication, not an FDA-approved branded product
- Clinicians come from partner telehealth networks (Beluga, Bask, Wasef Health)
- Availability varies by state
The cost of choosing this over Enhance MD: clinicians come from partner networks and availability varies by state.
Which one fits which patient
Choose Enhance MD if:
- you want to start on their timeline: online intake
- delivery works the way you want it to: home delivery
- you would get real value from the lowest first month anywhere on this list, on both compounds
- the level of clinical contact suits you: 10,000+ patients treated
Choose Refills if:
- the level of clinical contact suits you: free 24/7 health concierge
- you would get real value from $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing
- you want the full price in front of you before completing an intake
- you want the price you sign up at to survive titration
Where each program concedes something
On price. The monthly gap is 2.0x in Enhance MD's favor. Whether that is a saving or a false economy turns on one thing: what you pay in month two is the number that is missing.
On commitment. Neither publishes a multi-month discount, so both are month-to-month decisions and neither asks you to prepay for a response you have not had yet. Neither publishes financing options, so plan for the full amount each month.
On clinical contact. The support models differ — 10,000+ patients treated against free 24/7 health concierge — and that difference is felt in week two, not week one.
On medication. Enhance MD covers compounded semaglutide and compounded tirzepatide; Refills covers compounded semaglutide and GIP+GLP-1 dual agonist. Neither locks you out of a molecule the other offers, so this is unlikely to be the deciding factor.
The clinical evidence, separated from the marketing
Neither Enhance MD nor Refills manufactures the molecule it prescribes, and the clinical evidence behind GLP-1 treatment belongs to the drug rather than to any platform selling access to it.
The FDA publishes an ongoing record of semaglutide products marketed for diabetes and weight loss, and which of them it has actually approved, per FDA.
Dosing errors are the failure mode the FDA has flagged most often with unapproved GLP-1 products, particularly where a patient draws the dose themselves, per FDA.
Read alongside the pricing above, that is the case for treating the medication decision as clinical and the provider decision as commercial. They are not the same choice.
Enhance MD vs Refills: common questions
What happens when Enhance MD's promotional price ends?
The ongoing flat rate is higher than the $49 introductory month and is not prominently published before intake. Ask for it before the first charge, since it governs almost the entire cost of a year of treatment.
Which is cheaper to start, Enhance MD or Refills?
Enhance MD, at $49 against $99. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
Do Enhance MD or Refills take insurance?
Both run on a direct-pay basis: you pay the platform and it does not bill your insurer. Neither publishes HSA/FSA acceptance, so budget the full amount as out-of-pocket spending.
Which has more patient reviews, Enhance MD or Refills?
Enhance MD, with 10,482 against 7,400. Ratings across this market cluster tightly, so volume is the more useful signal: it indicates how much operational load the platform has already absorbed, not how good the medication is.
How fast can I start with Enhance MD compared with Refills?
Enhance MD advertises online intake, with home delivery. Refills advertises 3-minute approval quiz, with free, fast and discreet shipping on every order. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
The verdict
Enhance MD is the cheaper of the two to run at $49/mo, but a full-year total is only computable for one side of this comparison, so treat that as a directional finding rather than a settled one.
Refills's case is $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing; its cost: clinicians come from partner networks and availability varies by state.
Neither choice is irreversible. Start with the program whose weaknesses you can tolerate, and reassess at month three when you know how you respond to the medication.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Enhance MD or Refills, and does not sell treatment. Read our ranking methodology.