Budget vs premium
Enhance MD vs Novi: Which Costs Less Over 12 Months? (2026)
Enhance MD $49/mo vs Novi $133/mo. 2026 comparison of pricing, medication and support, with 12-month totals rather than first-month offers.
Published · Pricing as published in our provider dataset, synced · Editorial scores 8.4 and 7.0 out of 10
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Anyone shortlisting Enhance MD against Novi is choosing between two direct-pay GLP-1 programs that solve the same problem in materially different ways.
On the number that matters after the first month, they are not close: Enhance MD runs $49/mo against $133/mo at Novi — 2.7x more, every month, for the same drug class.
Everything here is drawn from each provider's own published pricing and program detail, then extended into six- and twelve-month totals so the two become comparable. Undisclosed pricing is treated as a finding, not rounded into an estimate.
The short answer
- Lowest ongoing rate
- Enhance MD — $49/mo against $133/mo, though only one of the two publishes enough to total a full year.
- Most predictable bill
- Enhance MD — Flat rate at every dose, so titration does not change what you are charged.
- Least friction to get going
- Novi — Online intake, then free 2-day shipping with every order.
- Longest public track record
- Novi — 50,124 patient reviews against 10,482.
The short version: Enhance MD vs Novi
Read the second row before the first: the advertised price and the price you actually run at are frequently different numbers.
| Enhance MD | Novi | |
|---|---|---|
| Advertised price | Semaglutide from $49, tirzepatide from $99, first month | Semaglutide from $133/mo, tirzepatide from $166/mo |
| Rate after promotions | $49/mo | $133/mo |
| Pricing structure | Flat rate at every dose | Published rate per medication |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide and compounded tirzepatide |
| Tirzepatide | $99/mo | $166/mo |
| Price transparency | Partly published | Published upfront |
| Shipping | Home delivery | Free 2-day shipping with every order |
| Support model | No coaching program stated | No coaching program stated |
| Patient reviews | 10,482 | 50,124 |
| eRxDoctor score | 8.4/10 | 7.0/10 |
What Enhance MD and Novi actually cost over a year
Almost every complaint about telehealth GLP-1 pricing traces back to comparing month one instead of month twelve. The totals below are the honest version, built from the rates each provider publishes.
| Enhance MD | Novi | |
|---|---|---|
| First month | $49 | $133 |
| Months 2 onward | Not published | $133/mo |
| 6-month total | Not computable | $798 |
| 12-month total | Not computable | $1,596 |
| Best published plan | No multi-month discount published | No multi-month discount published |
A like-for-like annual total is not available for Enhance MD: the ongoing flat rate is higher than the $49 introductory month and is not prominently published before intake. Treat any comparison that quotes one as an estimate someone else has made for you.
Enhance MD is cheaper. Does that make it better?
Before treating the cheaper option as the obvious one, it is worth naming what the more expensive one includes — at Novi that is no long-term contract, cancel anytime, plus free 2-day shipping with every order.
On the other side, Enhance MD leads with the lowest first month anywhere on this list, on both compounds — with one qualification: what you pay in month two is the number that is missing.
For a patient who has taken a GLP-1 before, knows how they titrate and needs a reliable monthly refill, the cheaper program is usually the correct one and the premium is a donation. For a first prescription, the calculus changes.
Inside the Enhance MD program
Enhance MD offers semaglutide from $49 and tirzepatide from $99 for your first month, with flat-rate pricing that stays the same at every dose, no fee escalation. In this pairing, its distinguishing feature is the lowest first month anywhere on this list, on both compounds.
The process is online intake, then home delivery. On money, expect flat rate at every dose — partly published.
What continues after the first shipment: 10,000+ patients treated. Formulary: compounded semaglutide and compounded tirzepatide.
Enhance MD pros
- No hidden fees at higher doses
- 10,000+ patients treated, meaningful real-world clinical volume
- Both semaglutide and tirzepatide available on one platform
- Flat-rate pricing: the same price at every dose, with no fee escalation during titration
Enhance MD cons
- Ongoing flat-rate pricing not always prominently published before intake
- The $49/$99 rates are first-month introductory prices; ongoing flat rate is higher
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
The cost of choosing this over Novi: what you pay in month two is the number that is missing.
Novi in detail
$200 OFF - GLP-1 for $133 Today What it is really selling here is the narrowest gap here between semaglutide and tirzepatide pricing, at $133 and $166.
You start with online intake; medication arrives via free 2-day shipping with every order. The price behaves as published rate per medication.
On the clinical side, no long-term contract, cancel anytime, prescribing compounded semaglutide and compounded tirzepatide.
Novi pros
- No insurance required and no long-term contract, cancel anytime
- $200 off promotion brings GLP-1 to $133 today
- Free 2-day shipping included with every order
- Both compounded semaglutide and tirzepatide available
Novi cons
- No published outcome or weight loss guarantee
- Tirzepatide ($166) costs more than the semaglutide entry rate
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
The reservation worth holding, particularly next to Enhance MD: the $133 rate depends on a $200-off promotion and there is no outcome guarantee.
Picking between them
Choose Enhance MD if:
- delivery works the way you want it to: home delivery
- you want to start on their timeline: online intake
- you want the price you sign up at to survive titration
- the monthly rate is the constraint — $49/mo against $133/mo
Choose Novi if:
- delivery works the way you want it to: free 2-day shipping with every order
- you want to start on their timeline: online intake
- the level of clinical contact suits you: no long-term contract, cancel anytime
- you would get real value from the narrowest gap here between semaglutide and tirzepatide pricing, at $133 and $166
Honest trade-offs
On price. The monthly gap is 2.7x in Enhance MD's favor. Whether that is a saving or a false economy turns on one thing: what you pay in month two is the number that is missing.
On medication. Enhance MD covers compounded semaglutide and compounded tirzepatide; Novi covers compounded semaglutide and compounded tirzepatide. Neither locks you out of a molecule the other offers, so this is unlikely to be the deciding factor.
On clinical contact. Enhance MD provides 10,000+ patients treated. Novi provides no long-term contract, cancel anytime. Both are asynchronous-first services and neither replaces a physician who can examine you.
On predictability. The pricing structures differ (flat rate at every dose versus published rate per medication), and structure, not headline rate, determines the twelve-month bill.
What the trials and the FDA say
Both platforms sell access to the same drug class, so the clinical record below applies equally to each.
The FDA has published specific concerns about unapproved GLP-1 drugs sold for weight loss, including dosing errors made when patients measure their own doses, per FDA.
The FDA maintains a standing page on medications containing semaglutide, including what separates an approved product from a copy, per FDA.
None of that settles which of these two to use. It does mean the drug is doing the work, and you are choosing who supplies it and on what terms.
Enhance MD vs Novi: common questions
Is Enhance MD cheaper than Novi?
Yes, on the ongoing rate. Enhance MD runs $49/mo once promotional pricing ends, against $133/mo at Novi — a difference of 2.7x. Compare the first-month offers separately, because both providers discount entry differently from the rate you will actually be paying by month three.
Which is cheaper to start, Enhance MD or Novi?
Enhance MD, at $49 against $133. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
Is Enhance MD or Novi better for a first GLP-1 prescription?
First-timers usually get more from clinical access than from a lower rate, because the first two months are where most people stop. On that basis Enhance MD has the stronger case; after month three, cost should take over.
Can I switch from Enhance MD to Novi later?
Nothing stops you. The friction is administrative rather than clinical: a new intake, a new prescriber, and a delivery gap if you time it badly. Move while you still have two weeks of medication in the fridge.
Do Enhance MD and Novi prescribe the same medication?
Both dispense compounded GLP-1 preparations. Enhance MD lists compounded semaglutide and compounded tirzepatide and Novi lists compounded semaglutide and compounded tirzepatide, so the molecules overlap even where the formulary does not match exactly.
How fast can I start with Enhance MD compared with Novi?
Enhance MD advertises online intake, with home delivery. Novi advertises online intake, with free 2-day shipping with every order. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
The verdict
Enhance MD is the cheaper of the two to run at $49/mo, but a full-year total is only computable for one side of this comparison, so treat that as a directional finding rather than a settled one.
Novi's case is the narrowest gap here between semaglutide and tirzepatide pricing, at $133 and $166; its cost: the $133 rate depends on a $200-off promotion and there is no outcome guarantee.
Get the maintenance-dose price in writing from whichever one you pick. That single question prevents most of the regret in this category.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Enhance MD or Novi, and does not sell treatment. Read our ranking methodology.