Budget vs premium
Yucca Health vs Refills: Which Costs Less Over 12 Months? (2026)
Yucca Health or Refills? Side-by-side 2026 pricing, medication and service comparison, extended to six and twelve-month totals.
Published · Pricing as published in our provider dataset, synced · Editorial scores 9.5 and 7.7 out of 10
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The choice between Yucca Health and Refills usually comes down to one difference that neither homepage puts in its headline.
Yucca Health costs 47% more per month than Refills once promotional pricing is out of the picture ($146/mo against $99/mo). Over a year that gap compounds into real money, and the question is what it buys.
Below, the two programs are set against the things that change the bill — the advertised rate, the rate after the promotion expires, the medication class and the inclusions. Where a figure is not published, that is stated rather than estimated.
The short answer
- Lowest 12-month cost
- Refills — $1,188 against $1,752 at Yucca Health, on each provider's own best published pricing.
- Most predictable bill
- Yucca Health — Price locked for the life of the plan, so titration does not change what you are charged.
- Fastest route to a first shipment
- Yucca Health — Approval within 24 hours, then UPS 2-Day Air from a licensed U.S. compounding pharmacy.
- Easiest to pay for
- Yucca Health — Klarna, Afterpay and Affirm.
Yucca Health vs Refills: the specification
This is the whole comparison in one screen. The sections underneath explain which of these rows should decide it.
| Yucca Health | Refills | |
|---|---|---|
| Advertised price | Semaglutide $146/mo, tirzepatide $258/mo | GLP-1 from $99/mo, about $5 a day |
| Rate after promotions | $146/mo | $99/mo |
| Pricing structure | Price locked for the life of the plan | Flat rate at every dose |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide and GIP+GLP-1 dual agonist |
| Price transparency | Published upfront | Published upfront |
| Tirzepatide | $258/mo | Available |
| Support model | No coaching program stated | No coaching program stated |
| Shipping | UPS 2-Day Air from a licensed U.S. compounding pharmacy | Free, fast and discreet shipping on every order |
| Patient reviews | 36,958 | 7,400 |
| eRxDoctor score | 9.5/10 | 7.7/10 |
The real cost: six months and twelve
The cheapest first month and the cheapest year are frequently different providers. Here is what each one costs across a realistic course of treatment, on published pricing.
| Yucca Health | Refills | |
|---|---|---|
| First month | $146 | $99 |
| Months 2 onward | $146/mo | $99/mo |
| 6-month total | $876 | $594 |
| 12-month total | $1,752 | $1,188 |
| Best published plan | 6-month semaglutide plan at $875 — $1,752/yr | No multi-month discount published |
The twelve-month spread is $564. That is the number to hold Yucca Health against: it has to justify roughly $47 extra every month.
Is Yucca Health worth the premium?
The gap runs to 47% a month. What Yucca Health offers for it: personalized treatment plans from board-certified providers, plus UPS 2-Day Air from a licensed U.S. compounding pharmacy.
Refills's answer is $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing. What it does not carry: clinicians come from partner networks and availability varies by state.
For a patient who has taken a GLP-1 before, knows how they titrate and needs a reliable monthly refill, the cheaper program is usually the correct one and the premium is a donation. For a first prescription, the calculus changes.
Inside the Yucca Health program
Yucca Health (TryYucca) review 2026: personalized compounded semaglutide from $146/month and tirzepatide from $258/month. Fast 24-hr approval, UPS 2-Day Air, Klarna/Affirm/Afterpay accepted. What it is really selling here is a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market.
Practically: approval within 24 hours, UPS 2-Day Air from a licensed U.S. compounding pharmacy, and a pricing model that is price locked for the life of the plan.
Personalized treatment plans from board-certified providers. The formulary covers compounded semaglutide and compounded tirzepatide.
Yucca Health pros
- Compounded semaglutide from $146/month, one of the lowest prices from a legitimate GLP-1 telehealth provider
- Compounded tirzepatide from $258/month, dual GIP/GLP-1 mechanism for higher average weight loss
- 6-month semaglutide plan at $875 locks in the best per-month rate
- Three Buy Now Pay Later options: Klarna, Afterpay, and Affirm
Yucca Health cons
- Does not accept health insurance
- No branded FDA-approved medications (Ozempic, Wegovy, Zepbound)
- Cancellation terms for multi-month plans should be confirmed before purchase
Against Refills specifically, the trade you are making: no branded medication, no insurance billing and no outcome guarantee.
How Refills works
Refills offers personalized compounded GLP-1 from $99/month (~$5/day) with flat pricing, the same price at every dosage, plus free discreet shipping, 24/7 health concierge support, and no membership or app fees. In this pairing, its distinguishing feature is $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing.
From signup to first shipment: 3-minute approval quiz, then free, fast and discreet shipping on every order. Billing follows a flat rate at every dose structure.
What continues after the first shipment: free 24/7 health concierge. Formulary: compounded semaglutide and GIP+GLP-1 dual agonist.
Refills pros
- Free 24/7 Health Concierge support
- Free, fast, and discreet shipping on every order
- No insurance required, 3-minute approval quiz
- LegitScript-certified U.S. compounding pharmacies with third-party USP testing
Refills cons
- Compounded medication, not an FDA-approved branded product
- Clinicians come from partner telehealth networks (Beluga, Bask, Wasef Health)
- Availability varies by state
The cost of choosing this over Yucca Health: clinicians come from partner networks and availability varies by state.
Yucca Health or Refills: matching the program to the patient
Choose Yucca Health if:
- delivery works the way you want it to: UPS 2-Day Air from a licensed U.S. compounding pharmacy
- you are willing to commit for a term in exchange for a lower effective rate (6-month semaglutide plan at $875)
- what it leads on is worth paying for in your case: a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market
- the level of clinical contact suits you: personalized treatment plans from board-certified providers
Choose Refills if:
- delivery works the way you want it to: free, fast and discreet shipping on every order
- you want to start on their timeline: 3-minute approval quiz
- the level of clinical contact suits you: free 24/7 health concierge
- the feature you would actually use: $99 flat at every dosage, from LegitScript-certified pharmacies with third-party USP testing
The trade-offs, stated plainly
On price. The monthly gap is 47% in Refills's favor. Whether that is a saving or a false economy turns on one thing: clinicians come from partner networks and availability varies by state.
On clinical contact. Yucca Health provides personalized treatment plans from board-certified providers. Refills provides free 24/7 health concierge. Both are asynchronous-first services and neither replaces a physician who can examine you.
On medication. Yucca Health covers compounded semaglutide and compounded tirzepatide; Refills covers compounded semaglutide and GIP+GLP-1 dual agonist. Neither locks you out of a molecule the other offers, so this is unlikely to be the deciding factor.
On access. Yucca Health advertises approval within 24 hours and UPS 2-Day Air from a licensed U.S. compounding pharmacy; Refills advertises 3-minute approval quiz and free, fast and discreet shipping on every order. Coverage differs too — all 50 states against availability varies by state — which decides the question before price does if you are in a restricted state.
The clinical evidence, separated from the marketing
It is worth separating the program from the pharmacology. What follows is true of the medication regardless of which of these two writes the prescription.
The NIH position is that weight-management medication works alongside changes in eating and activity, not instead of them, per NIH, NIDDK.
Cardiovascular benefit has been demonstrated for semaglutide in a specific population: adults with overweight or obesity and existing cardiovascular disease but no diabetes, per NEJM, SELECT.
Read alongside the pricing above, that is the case for treating the medication decision as clinical and the provider decision as commercial. They are not the same choice.
Yucca Health vs Refills: common questions
Is Refills cheaper than Yucca Health?
Yes, on the ongoing rate. Refills runs $99/mo once promotional pricing ends, against $146/mo at Yucca Health — a difference of 47%. Compare the first-month offers separately, because both providers discount entry differently from the rate you will actually be paying by month three.
Which costs less over a year, Yucca Health or Refills?
Refills, at roughly $1,188 for twelve months against $1,752 at Yucca Health, using each provider's own best published pricing. Those totals cover medication and program fees as published; they exclude anything a provider bills separately, and they assume you stay on the same plan for the full year.
Which is cheaper to start, Yucca Health or Refills?
Refills, at $99 against $146. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
Do Yucca Health and Refills prescribe the same medication?
Both dispense compounded GLP-1 preparations. Yucca Health lists compounded semaglutide and compounded tirzepatide and Refills lists compounded semaglutide and GIP+GLP-1 dual agonist, so the molecules overlap even where the formulary does not match exactly.
Can I switch from Yucca Health to Refills later?
You can, and people do — usually when an introductory price expires. Budget for a repeat intake and a short overlap in supply, and confirm what happens to any unused portion of a multi-month plan before you cancel it.
Are Yucca Health and Refills legitimate?
Both are licensed telehealth platforms that route a prescription through a clinician review before anything is dispensed; neither sells medication without one. Yucca Health operates on price locked for the life of the plan with pricing published upfront, Refills on flat rate at every dose, published upfront. The meaningful due diligence is on the medication category and the terms, not on whether the platforms are real.
Is Yucca Health or Refills better for a first GLP-1 prescription?
For a first prescription, weight support over price. Yucca Health offers more contact (personalized treatment plans from board-certified providers), which matters most in the first eight weeks when side effects and titration questions are at their peak. Once you know how you tolerate the medication, the cheaper program becomes the rational choice.
The verdict
Strictly on cost, Refills takes it — $1,188 to $1,752 over twelve months.
Yucca Health earns the difference in one situation: when a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market is something you will genuinely use. If you cannot say that out loud, take the cheaper program.
The failure mode here is not picking the wrong platform; it is stopping treatment because the bill moved. Choose the one whose bill you can predict.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Yucca Health or Refills, and does not sell treatment. Read our ranking methodology.