Published price vs quote-only
Yucca Health vs Directmeds: Which One Publishes Its Price? (2026)
Yucca Health $146/mo vs Directmeds quotes after intake. 2026 comparison of pricing, medication and support, with 12-month totals rather than first-month.
Published · Pricing as published in our provider dataset, synced · Editorial scores 9.5 and 7.8 out of 10
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Anyone shortlisting Yucca Health against Directmeds is choosing between two direct-pay GLP-1 programs that solve the same problem in materially different ways.
One of these programs can be evaluated before you start it and one cannot. Yucca Health lists Semaglutide $146/mo, tirzepatide $258/mo; with Directmeds, standard post-promotional pricing is not disclosed upfront.
Everything here is drawn from each provider's own published pricing and program detail, then extended into six- and twelve-month totals so the two become comparable. Where a provider quotes only after intake, that is recorded as the answer rather than replaced with a guess.
The short answer
- Easier to price in advance
- Yucca Health — Semaglutide $146/mo, tirzepatide $258/mo. The other side quotes after intake, so a like-for-like total is not available before you apply.
- Most predictable bill
- Yucca Health — Price locked for the life of the plan, so titration does not change what you are charged.
- Tirzepatide access
- Yucca Health — Tirzepatide at $258/mo; the other side publishes semaglutide only.
- Longest public track record
- Yucca Health — 36,958 patient reviews against 3,400.
Yucca Health and Directmeds, side by side
Read the second row before the first: the advertised price and the price you actually run at are frequently different numbers.
| Yucca Health | Directmeds | |
|---|---|---|
| Advertised price | Semaglutide $146/mo, tirzepatide $258/mo | 50% off the first month |
| Rate after promotions | $146/mo | not published before intake |
| Pricing structure | Price locked for the life of the plan | Quoted only after intake |
| Medication | Compounded semaglutide and compounded tirzepatide | GLP-1 medication via licensed telehealth prescribing |
| Price transparency | Published upfront | Quote only, after intake |
| Support model | No coaching program stated | No coaching program stated |
| Tirzepatide | $258/mo | Not published |
| Payment options | Klarna, Afterpay and Affirm | Card only, no financing published |
| Shipping | UPS 2-Day Air from a licensed U.S. compounding pharmacy | Nationwide shipping, no insurance required |
| Patient reviews | 36,958 | 3,400 |
| eRxDoctor score | 9.5/10 | 7.8/10 |
The real cost: six months and twelve
Almost every complaint about telehealth GLP-1 pricing traces back to comparing month one instead of month twelve. Below, both are carried out to six and twelve months so the comparison holds at the point it matters.
| Yucca Health | Directmeds | |
|---|---|---|
| First month | $146 | Not published |
| Months 2 onward | $146/mo | Not published |
| 6-month total | $876 | Not computable |
| 12-month total | $1,752 | Not computable |
| Best published plan | 6-month semaglutide plan at $875 — $1,752/yr | No multi-month discount published |
A like-for-like annual total is not available for Directmeds: standard post-promotional pricing is not disclosed upfront. Treat any comparison that quotes one as an estimate someone else has made for you.
What you know before you hand over a medical history
Yucca Health states its terms upfront: Semaglutide $146/mo, tirzepatide $258/mo, price locked for the life of the plan. You can decide whether it fits your budget without giving anyone a medical history.
Directmeds runs the other way around — standard post-promotional pricing is not disclosed upfront. There are defensible reasons for that; personalized plans genuinely do vary. The practical effect is still that you cannot comparison-shop it, and a completed intake is exactly the moment a quote lands with the most leverage.
If you do go through Directmeds's intake, ask for the month-two price in writing before you pay for month one. That single question resolves most of the disclosure gap.
Yucca Health: what you are buying
Yucca Health (TryYucca) review 2026: personalized compounded semaglutide from $146/month and tirzepatide from $258/month. Fast 24-hr approval, UPS 2-Day Air, Klarna/Affirm/Afterpay accepted.
Intake is approval within 24 hours. Fulfillment is UPS 2-Day Air from a licensed U.S. compounding pharmacy. The commercial terms are price locked for the life of the plan, published upfront.
What continues after the first shipment: personalized treatment plans from board-certified providers. Formulary: compounded semaglutide and compounded tirzepatide.
Yucca Health pros
- Personalized treatment plans based on your health history and weight loss goals
- UPS 2-Day Air shipping on most orders from a licensed U.S. compounding pharmacy
- Fast 24-hour approval with fully online intake, no clinic visits required
- Three Buy Now Pay Later options: Klarna, Afterpay, and Affirm
Yucca Health cons
- No weight loss warranty or outcome guarantee
- Cancellation terms for multi-month plans should be confirmed before purchase
- No branded FDA-approved medications (Ozempic, Wegovy, Zepbound)
The cost of choosing this over Directmeds: no branded medication, no insurance billing and no outcome guarantee.
Inside the Directmeds program
The pitch is a half-price first month and nationwide shipping with no insurance step. Directmeds is a licensed telehealth platform offering GLP-1 medications with a 50% first-month discount and nationwide shipping.
Getting started means online intake, after which nationwide shipping, no insurance required. Pricing runs on a quoted only after intake basis, quote only, after intake.
On the clinical side, licensed telehealth prescribing, prescribing GLP-1 medication via licensed telehealth prescribing.
Directmeds pros
- Licensed telehealth prescribing model
- 50% off first month for new patients
- Nationwide shipping, no insurance required
Directmeds cons
- Standard (post-promo) pricing is not clearly disclosed upfront
The reservation worth holding, particularly next to Yucca Health: a discount off an undisclosed price is not a price.
Who each program is actually built for
Choose Yucca Health if:
- you would rather use the platform with the longer public record (36,958 reviews)
- you need to spread the cost — Klarna, Afterpay and Affirm
- you want tirzepatide available without changing provider later
- you want the price you sign up at to survive titration
Choose Directmeds if:
- delivery works the way you want it to: nationwide shipping, no insurance required
- you want to start on their timeline: online intake
- the level of clinical contact suits you: licensed telehealth prescribing
- the feature you would actually use: a half-price first month and nationwide shipping with no insurance step
Where each program concedes something
On price. Only Yucca Health publishes a rate you can plan against (Semaglutide $146/mo, tirzepatide $258/mo). The other quotes after intake, which is a cost of a different kind: you cannot budget the year in advance.
On medication. Yucca Health covers compounded semaglutide and compounded tirzepatide; Directmeds covers GLP-1 medication via licensed telehealth prescribing. Only Yucca Health publishes a tirzepatide route, which matters if semaglutide underdelivers.
On clinical contact. The support models differ — personalized treatment plans from board-certified providers against licensed telehealth prescribing — and that difference is felt in week two, not week one.
On predictability. Price locked for the life of the plan at Yucca Health, against quoted only after intake at Directmeds. The more predictable structure is worth a premium to anyone who has been surprised by a telehealth invoice before.
The medication, not the platform
The efficacy data people cite when comparing these platforms is not platform data. It comes from trials of the underlying medication, and it applies to both.
NIDDK frames medication as one component of obesity treatment rather than a replacement for the rest of it, per NIH, NIDDK.
The FDA has published specific concerns about unapproved GLP-1 drugs sold for weight loss, including dosing errors made when patients measure their own doses, per FDA.
Use it as the floor for the conversation with whichever prescriber you end up with, rather than as a reason to pick one platform over the other.
Yucca Health vs Directmeds: common questions
Which has more patient reviews, Yucca Health or Directmeds?
Yucca Health, with 36,958 against 3,400. Ratings across this market cluster tightly, so volume is the more useful signal: it indicates how much operational load the platform has already absorbed, not how good the medication is.
Is Yucca Health or Directmeds better for a first GLP-1 prescription?
For a first prescription, weight support over price. Yucca Health offers more contact (personalized treatment plans from board-certified providers), which matters most in the first eight weeks when side effects and titration questions are at their peak. Once you know how you tolerate the medication, the cheaper program becomes the rational choice.
Can I switch from Yucca Health to Directmeds later?
Nothing stops you. The friction is administrative rather than clinical: a new intake, a new prescriber, and a delivery gap if you time it badly. Move while you still have two weeks of medication in the fridge, and read the cancellation terms on any prepaid plan before you do.
Does Yucca Health or Directmeds offer tirzepatide?
Yucca Health does, at $258/mo. Directmeds publishes GLP-1 medication via licensed telehealth prescribing only, so moving to tirzepatide would mean moving provider — a new intake, a new price, and the loss of any rate you had locked in.
Do Yucca Health and Directmeds prescribe the same medication?
Both dispense compounded GLP-1 preparations. Yucca Health lists compounded semaglutide and compounded tirzepatide and Directmeds lists GLP-1 medication via licensed telehealth prescribing, so the molecules overlap even where the formulary does not match exactly.
The verdict
Neither of these two publishes enough for a clean cost verdict, which is itself the finding. Yucca Health leads on a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market; Directmeds leads on a half-price first month and nationwide shipping with no insurance step.
Before choosing either, get the maintenance-dose price in writing. Without it, any comparison — including this one — is working with half the information.
Get the maintenance-dose price in writing from whichever one you pick. That single question prevents most of the regret in this category.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Yucca Health or Directmeds, and does not sell treatment. Read our ranking methodology.