Tirzepatide access
Novi vs TMates: Which One Offers Tirzepatide? (2026)
Compare Novi and TMates on real cost over 12 months, medication type, price stability and support. Independent 2026 analysis, no first-month gimmicks.
Published · Pricing as published in our provider dataset, synced · Editorial scores 7.0 and 7.0 out of 10
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Both Novi and TMates will get a GLP-1 prescription to your door without an in-person visit. The question is what the year after that first shipment looks like.
Novi will prescribe tirzepatide, the dual GIP/GLP-1 agonist; TMates, on published information, will not. If you already know you want tirzepatide, that decides it before price enters the conversation.
What follows is a like-for-like read of both programs: entry pricing, maintenance pricing, formulary, support model and the terms attached to each. Anything a provider declines to disclose is marked undisclosed rather than filled in.
The short answer
- Lowest 12-month cost
- Novi — $1,596 against $2,388 at TMates, on each provider's own best published pricing.
- Most predictable bill
- TMates — Flat rate at every dose, so titration does not change what you are charged.
- Tirzepatide access
- Novi — Tirzepatide at $166/mo; the other side publishes semaglutide only.
- Most support included
- TMates — 24/7 access to U.S.-based doctors, not just messaging.
Side-by-side comparison
Every figure below is the provider's own published number. The blank spaces are theirs, not ours.
| Novi | TMates | |
|---|---|---|
| Advertised price | Semaglutide from $133/mo, tirzepatide from $166/mo | $199/mo at every dose, no step-up fees |
| Rate after promotions | $133/mo | $199/mo |
| Pricing structure | Published rate per medication | Flat rate at every dose |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide |
| Tirzepatide | $166/mo | Not published |
| State coverage | Not published | All 50 states |
| How fast you start | Online intake | Virtual check-in appointments |
| Membership fee | None | None |
| Payment options | Card only, no financing published | Card only, no financing published |
| Patient reviews | 50,124 | 21,970 |
| eRxDoctor score | 7.0/10 | 7.0/10 |
The real cost: six months and twelve
Trial data runs to 68 and 72 weeks; the pricing people compare runs to 30 days. The figures underneath convert both offers into what you will have spent by month six and month twelve.
| Novi | TMates | |
|---|---|---|
| First month | $133 | $199 |
| Months 2 onward | $133/mo | $199/mo |
| 6-month total | $798 | $1,194 |
| 12-month total | $1,596 | $2,388 |
| Best published plan | No multi-month discount published | No multi-month discount published |
Over a year that is a $792 difference, in Novi's favor. Whether it is the right call depends on whether TMates gives you $66 a month of something you will use.
Semaglutide, tirzepatide, and having somewhere to go next
Semaglutide is a GLP-1 receptor agonist. Tirzepatide adds GIP activity, and in head-to-head trial data it has produced larger average weight reductions. That does not make it the right first choice for everyone — it is typically more expensive and the side-effect profile is its own conversation — but it is the usual next step when semaglutide underdelivers.
Novi publishes both, with tirzepatide at $166/mo. TMates publishes compounded semaglutide, so switching molecules would mean switching provider, repeating an intake and losing whatever pricing you had locked in.
Optionality has a price and it is usually small. Weigh it against the cost of restarting the whole process elsewhere in six months.
Inside the Novi program
$200 OFF - GLP-1 for $133 Today
The process is online intake, then free 2-day shipping with every order. On money, expect published rate per medication — published upfront.
What continues after the first shipment: no long-term contract, cancel anytime. Formulary: compounded semaglutide and compounded tirzepatide.
Novi pros
- Competitive pricing: semaglutide from $133/month and tirzepatide from $166/month
- Largest patient base on this list, 50,000+ patients, signaling operational maturity
- Both compounded semaglutide and tirzepatide available
- Free 2-day shipping included with every order
Novi cons
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
- Tirzepatide ($166) costs more than the semaglutide entry rate
- No published outcome or weight loss guarantee
Set beside TMates, the thing to weigh: the $133 rate depends on a $200-off promotion and there is no outcome guarantee.
A closer look at TMates
TMates positions itself on one flat $199 that survives every titration step, with doctors rather than a message queue behind it. $199/month, every dose, no step-up fees
Getting started means virtual check-in appointments, after which medication formulated in U.S. facilities. Pricing runs on a flat rate at every dose basis, published upfront.
Ongoing care is 24/7 access to U.S.-based doctors, not just messaging, and the medication list runs to compounded semaglutide.
TMates pros
- Virtual check-in appointments for ongoing medical oversight
- Flat $199/month at every dose, no step-up fees as dosage escalates
- 24/7 access to U.S.-based doctors, not just messaging support
- Licensed coverage in all 50 states
TMates cons
- Compounded semaglutide only, limited public detail on tirzepatide availability
- $199/month is higher than the cheapest compounded options
- No branded Ozempic, Wegovy, or Zepbound
Where it gives ground to Novi: semaglutide only, and $199 is well above the cheapest compounded options.
Which one fits which patient
Choose Novi if:
- you want tirzepatide available without changing provider later
- the monthly rate is the constraint — $133/mo against $199/mo
- what it leads on is worth paying for in your case: the narrowest gap here between semaglutide and tirzepatide pricing, at $133 and $166
- the twelve-month total is what you are optimizing ($1,596 against $2,388)
Choose TMates if:
- delivery works the way you want it to: medication formulated in U.S. facilities
- you want to start on their timeline: virtual check-in appointments
- you are in a state where GLP-1 telehealth coverage is patchy
- you want the price you sign up at to survive titration
Where each program concedes something
On price. The monthly gap is 50% in Novi's favor. Whether that is a saving or a false economy turns on one thing: the $133 rate depends on a $200-off promotion and there is no outcome guarantee.
On commitment. Neither publishes a multi-month discount, so both are month-to-month decisions and neither asks you to prepay for a response you have not had yet. Neither publishes financing options, so plan for the full amount each month.
On predictability. Published rate per medication at Novi, against flat rate at every dose at TMates. The more predictable structure is worth a premium to anyone who has been surprised by a telehealth invoice before.
On access. Novi advertises online intake and free 2-day shipping with every order; TMates advertises virtual check-in appointments and medication formulated in U.S. facilities. Coverage differs too — not published against all 50 states — which decides the question before price does if you are in a restricted state.
What the trials and the FDA say
Weight loss percentages quoted in telehealth marketing come from trials neither Novi nor TMates ran. Here is the source material, and what regulators say alongside it.
NIDDK frames medication as one component of obesity treatment rather than a replacement for the rest of it, per NIH, NIDDK.
SURMOUNT-4 found that continuing tirzepatide maintained and extended weight reduction, while withdrawing it led to substantial regain, per JAMA, SURMOUNT-4.
None of that settles which of these two to use. It does mean the drug is doing the work, and you are choosing who supplies it and on what terms.
Novi vs TMates: common questions
Which is cheaper to start, Novi or TMates?
Novi, at $133 against $199. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
Which costs less over a year, Novi or TMates?
Novi, at roughly $1,596 for twelve months against $2,388 at TMates, using each provider's own best published pricing. Those totals cover medication and program fees as published; they exclude anything a provider bills separately, and they assume you stay on the same plan for the full year.
Is Novi cheaper than TMates?
Yes, on the ongoing rate. Novi runs $133/mo once promotional pricing ends, against $199/mo at TMates — a difference of 50%. Compare the first-month offers separately, because both providers discount entry differently from the rate you will actually be paying by month three.
Do Novi or TMates take insurance?
Both run on a direct-pay basis: you pay the platform and it does not bill your insurer. Neither publishes HSA/FSA acceptance, so budget the full amount as out-of-pocket spending.
Which has more patient reviews, Novi or TMates?
Novi, with 50,124 against 21,970. Ratings across this market cluster tightly, so volume is the more useful signal: it indicates how much operational load the platform has already absorbed, not how good the medication is.
How fast can I start with Novi compared with TMates?
Novi advertises online intake, with free 2-day shipping with every order. TMates advertises virtual check-in appointments, with medication formulated in U.S. facilities. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
Does Novi or TMates offer tirzepatide?
Novi does, at $166/mo. TMates publishes compounded semaglutide only, so moving to tirzepatide would mean moving provider — a new intake, a new price, and the loss of any rate you had locked in.
The verdict
On the numbers, Novi wins the year: $1,596 against $2,388. That is the default answer, and it is the right one for anyone who mainly needs a reliable prescription and a shipment that arrives.
The case for TMates is one flat $199 that survives every titration step, with doctors rather than a message queue behind it. That is worth $66 a month to some patients and nothing at all to others — be honest about which you are.
Both platforms are legitimate routes to a GLP-1 prescription. The decision is commercial, and it should be made with the twelve-month figure in front of you rather than the first-month one.
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See every provider in context on the weight loss rankings, or browse the full comparison index.
Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Novi or TMates, and does not sell treatment. Read our ranking methodology.