Budget vs premium
Enhance MD vs He & She MD: Which Costs Less Over 12 Months? (2026)
Enhance MD $49/mo, He & She MD $191/mo. What each 2026 program includes, what it omits, and which patient each one suits.
Published · Pricing as published in our provider dataset, synced · Editorial scores 8.4 and 7.0 out of 10
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He & She MD and Enhance MD both promise a fast route to GLP-1 treatment without an office visit. What they promise afterward is where they separate.
The gap is 3.9x: $49/mo at Enhance MD, $191/mo at He & She MD. Neither number is unusual for the market, but paying the higher one only makes sense if you can name what it adds.
Each program is read on its own published terms first, then against the other on the four things that decide satisfaction: price, predictability, formulary and access to a clinician. Undisclosed pricing is treated as a finding, not rounded into an estimate.
The short answer
- Lowest ongoing rate
- Enhance MD — $49/mo against $191/mo, though only one of the two publishes enough to total a full year.
- Most predictable bill
- Enhance MD — Flat rate at every dose, so titration does not change what you are charged.
- Quickest to start
- Enhance MD — Online intake, then home delivery.
- Widest medication choice
- He & She MD — compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection.
Enhance MD and He & She MD, side by side
Scan the pricing rows first, then the medication row. Those two settle most of these decisions between them.
| Enhance MD | He & She MD | |
|---|---|---|
| Advertised price | Semaglutide from $49, tirzepatide from $99, first month | Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo |
| Rate after promotions | $49/mo | $191/mo |
| Pricing structure | Flat rate at every dose | Introductory term, then renewal at a higher rate |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection |
| Support model | No coaching program stated | Coaching built into the plan |
| Shipping | Home delivery | Free expedited shipping with no upcharges |
| Price transparency | Partly published | Published upfront |
| Tirzepatide | $99/mo | $199/mo |
| Patient reviews | 10,482 | 4,180 |
| eRxDoctor score | 8.4/10 | 7.0/10 |
Enhance MD vs He & She MD on total cost, not entry price
Both providers lead with a number designed to get you through the intake. Here is what each one costs across a realistic course of treatment, on published pricing.
| Enhance MD | He & She MD | |
|---|---|---|
| First month | $49 | $139 |
| Months 2 onward | Not published | $191/mo |
| 6-month total | Not computable | $834 |
| 12-month total | Not computable | $1,980 |
| Best published plan | No multi-month discount published | No multi-month discount published |
A like-for-like annual total is not available for Enhance MD: the ongoing flat rate is higher than the $49 introductory month and is not prominently published before intake. Treat any comparison that quotes one as an estimate someone else has made for you.
Price escalation to plan for: He & She MD moves from $139 to $191, a 37% increase. Set a calendar reminder for the month it changes.
Where the extra money goes at He & She MD
Before treating the cheaper option as the obvious one, it is worth naming what the more expensive one includes — at He & She MD that is coaching app with 1:1 clinician messaging and progress tracking, no extra charge, plus free expedited shipping with no upcharges.
On the other side, Enhance MD leads with the lowest first month anywhere on this list, on both compounds — with one qualification: what you pay in month two is the number that is missing.
For a patient who has taken a GLP-1 before, knows how they titrate and needs a reliable monthly refill, the cheaper program is usually the correct one and the premium is a donation. For a first prescription, the calculus changes.
How Enhance MD works
The pitch is the lowest first month anywhere on this list, on both compounds. Enhance MD offers semaglutide from $49 and tirzepatide from $99 for your first month, with flat-rate pricing that stays the same at every dose, no fee escalation.
Practically: online intake, home delivery, and a pricing model that is flat rate at every dose.
Ongoing care is 10,000+ patients treated, and the medication list runs to compounded semaglutide and compounded tirzepatide.
Enhance MD pros
- No hidden fees at higher doses
- Both semaglutide and tirzepatide available on one platform
- 10,000+ patients treated, meaningful real-world clinical volume
- Cheapest first month for both compounds, semaglutide from $49 and tirzepatide from $99
Enhance MD cons
- Ongoing flat-rate pricing not always prominently published before intake
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
- The $49/$99 rates are first-month introductory prices; ongoing flat rate is higher
The reservation worth holding, particularly next to He & She MD: what you pay in month two is the number that is missing.
A closer look at He & She MD
He & She MD bundles compounded GLP-1 medication with a coaching app that carries 1:1 clinician messaging, GLP-1-specific guidance and progress tracking. Semaglutide injections start at $139/month, oral semaglutide and tirzepatide at $199/month, each a six-month introductory rate. Free expedited shipping, no membership fee, no insurance required. In this pairing, its distinguishing feature is three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO.
Intake is 2-3 minute intake with no payment required to check eligibility. Fulfillment is free expedited shipping with no upcharges. The commercial terms are introductory term, then renewal at a higher rate, published upfront.
Behind the prescription sits coaching app with 1:1 clinician messaging and progress tracking, no extra charge. Available medication: compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection.
He & She MD pros
- Fast 2-3 minute intake with no payment required to check eligibility
- No membership fee stacked on top of the medication price
- Free expedited shipping on every order, with no shipping upcharges
- Named, dual board-certified obesity-medicine Chief Medical Officer
He & She MD cons
- Compounded GLP-1s are not reviewed by the FDA for safety, efficacy or quality
- The 15-25 lbs in 12 weeks figure is self-reported retrospective data, not trial data
- Headline prices are 6-month intro rates that renew 30-45% higher
The cost of choosing this over Enhance MD: the headline rates are six-month terms that renew 30-45% higher.
Which one fits which patient
Choose Enhance MD if:
- you want to start on their timeline: online intake
- delivery works the way you want it to: home delivery
- the monthly rate is the constraint — $49/mo against $191/mo
- you want the price you sign up at to survive titration
Choose He & She MD if:
- you want the full price in front of you before completing an intake
- you want coaching app with 1:1 clinician messaging and progress tracking, no extra charge rather than a prescription alone
- the level of clinical contact suits you: coaching app with 1:1 clinician messaging and progress tracking, no extra charge
- you would get real value from three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO
Where each program concedes something
On price. The monthly gap is 3.9x in Enhance MD's favor. Whether that is a saving or a false economy turns on one thing: what you pay in month two is the number that is missing.
On access. Enhance MD advertises online intake and home delivery; He & She MD advertises 2-3 minute intake with no payment required to check eligibility and free expedited shipping with no upcharges. Neither publishes its state coverage, so confirm you are eligible before paying for anything.
On predictability. The pricing structures differ (flat rate at every dose versus introductory term, then renewal at a higher rate), and structure, not headline rate, determines the twelve-month bill.
On clinical contact. 10,000+ patients treated at Enhance MD; coaching app with 1:1 clinician messaging and progress tracking, no extra charge at He & She MD. Neither is a substitute for in-person care if you have complicating conditions, and both bill you directly rather than your insurer.
The clinical evidence, separated from the marketing
It is worth separating the program from the pharmacology. What follows is true of the medication regardless of which of these two writes the prescription.
The NIH position is that weight-management medication works alongside changes in eating and activity, not instead of them, per NIH, NIDDK.
STEP 1 recorded a mean 14.9% reduction in body weight over 68 weeks on weekly semaglutide, against 2.4% for placebo, per NEJM, STEP 1.
Neither platform's marketing changes any of that. It is the same evidence base whichever one takes your card.
Enhance MD vs He & She MD: common questions
Which is cheaper to start, Enhance MD or He & She MD?
Enhance MD, at $49 against $139. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
How fast can I start with Enhance MD compared with He & She MD?
Enhance MD advertises online intake, with home delivery. He & She MD advertises 2-3 minute intake with no payment required to check eligibility, with free expedited shipping with no upcharges. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
Do Enhance MD or He & She MD take insurance?
Both run on a direct-pay basis: you pay the platform and it does not bill your insurer. Neither publishes HSA/FSA acceptance, so budget the full amount as out-of-pocket spending.
What happens if I stop taking the medication?
Neither Enhance MD nor He & She MD penalizes you for stopping, but the medication does. The published follow-up data on withdrawal shows substantial regain, which is why the twelve-month totals above matter more than either provider's introductory offer.
Are Enhance MD and He & She MD legitimate?
Both are licensed telehealth platforms that route a prescription through a clinician review before anything is dispensed; neither sells medication without one. Enhance MD operates on flat rate at every dose with pricing partly published, He & She MD on introductory term, then renewal at a higher rate, published upfront. The meaningful due diligence is on the medication category and the terms, not on whether the platforms are real.
Is coaching included with Enhance MD or He & She MD?
He & She MD includes coaching app with 1:1 clinician messaging and progress tracking, no extra charge in the monthly price. Enhance MD provides 10,000+ patients treated, without a separate coaching program. If medication alone has failed you before, the bundled version is the one to price properly rather than the one to cut.
The verdict
Enhance MD is the cheaper of the two to run at $49/mo, but a full-year total is only computable for one side of this comparison, so treat that as a directional finding rather than a settled one.
He & She MD's case is three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO; its cost: the headline rates are six-month terms that renew 30-45% higher.
The failure mode here is not picking the wrong platform; it is stopping treatment because the bill moved. Choose the one whose bill you can predict.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Enhance MD or He & She MD, and does not sell treatment. Read our ranking methodology.