Published price vs quote-only
Directmeds vs He & She MD: Which One Publishes Its Price? (2026)
Directmeds or He & She MD? Side-by-side 2026 pricing, medication and service comparison, extended to six and twelve-month totals.
Published · Pricing as published in our provider dataset, synced · Editorial scores 7.8 and 7.0 out of 10
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If Directmeds and He & She MD are the two tabs still open, the deciding information is not on either homepage — it is in what happens after the first month.
A discount off an undisclosed number is not a price. Directmeds quotes after intake, while He & She MD states Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo on the way in — which makes one of these two comparable in advance and the other not.
Below, the two programs are set against the things that change the bill — the advertised rate, the rate after the promotion expires, the medication class and the inclusions. Every figure traces back to the provider's own published material, and the missing ones stay missing.
The short answer
- Easier to price in advance
- He & She MD — Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo. The other side quotes after intake, so a like-for-like total is not available before you apply.
- Most support for the money
- He & She MD — Coaching app with 1:1 clinician messaging and progress tracking, no extra charge.
- Tirzepatide access
- He & She MD — Tirzepatide at $199/mo; the other side publishes semaglutide only.
- Easiest to pay for
- Directmeds — Neither publishes financing; both expect the full amount monthly.
The short version: Directmeds vs He & She MD
This is the whole comparison in one screen. The sections underneath explain which of these rows should decide it.
| Directmeds | He & She MD | |
|---|---|---|
| Advertised price | 50% off the first month | Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo |
| Rate after promotions | not published before intake | $191/mo |
| Pricing structure | Quoted only after intake | Introductory term, then renewal at a higher rate |
| Medication | GLP-1 medication via licensed telehealth prescribing | Compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection |
| Price transparency | Quote only, after intake | Published upfront |
| Tirzepatide | Not published | $199/mo |
| Support model | No coaching program stated | Coaching built into the plan |
| Shipping | Nationwide shipping, no insurance required | Free expedited shipping with no upcharges |
| Payment options | Card only, no financing published | Card only, no financing published |
| Patient reviews | 3,400 | 4,180 |
| eRxDoctor score | 7.8/10 | 7.0/10 |
Cost over a full course of treatment
The cheapest first month and the cheapest year are frequently different providers. What matters is the total at the point most people are still in treatment, so both programs are extended to six and twelve months below.
| Directmeds | He & She MD | |
|---|---|---|
| First month | Not published | $139 |
| Months 2 onward | Not published | $191/mo |
| 6-month total | Not computable | $834 |
| 12-month total | Not computable | $1,980 |
| Best published plan | No multi-month discount published | No multi-month discount published |
A like-for-like annual total is not available for Directmeds: standard post-promotional pricing is not disclosed upfront. Treat any comparison that quotes one as an estimate someone else has made for you.
Price escalation to plan for: He & She MD moves from $139 to $191, a 37% increase. Set a calendar reminder for the month it changes.
Pricing you can check, and pricing you cannot
With He & She MD the arithmetic is available in advance — Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo, on introductory term, then renewal at a higher rate terms — so it can be compared against anything else on the market.
Directmeds runs the other way around — standard post-promotional pricing is not disclosed upfront. There are defensible reasons for that; personalized plans genuinely do vary. The practical effect is still that you cannot comparison-shop it, and a completed intake is exactly the moment a quote lands with the most leverage.
If you do go through Directmeds's intake, ask for the month-two price in writing before you pay for month one. That single question resolves most of the disclosure gap.
A closer look at Directmeds
Directmeds positions itself on a half-price first month and nationwide shipping with no insurance step. Directmeds is a licensed telehealth platform offering GLP-1 medications with a 50% first-month discount and nationwide shipping.
You start with online intake; medication arrives via nationwide shipping, no insurance required. The price behaves as quoted only after intake.
On the clinical side, licensed telehealth prescribing, prescribing GLP-1 medication via licensed telehealth prescribing.
Directmeds pros
- 50% off first month for new patients
- Nationwide shipping, no insurance required
- Licensed telehealth prescribing model
Directmeds cons
- Standard (post-promo) pricing is not clearly disclosed upfront
Against He & She MD specifically, the trade you are making: a discount off an undisclosed price is not a price.
Inside the He & She MD program
He & She MD bundles compounded GLP-1 medication with a coaching app that carries 1:1 clinician messaging, GLP-1-specific guidance and progress tracking. Semaglutide injections start at $139/month, oral semaglutide and tirzepatide at $199/month, each a six-month introductory rate. Free expedited shipping, no membership fee, no insurance required. Against Directmeds, that puts it in the position of the harder of the two to price in advance.
The process is 2-3 minute intake with no payment required to check eligibility, then free expedited shipping with no upcharges. On money, expect introductory term, then renewal at a higher rate — published upfront.
Behind the prescription sits coaching app with 1:1 clinician messaging and progress tracking, no extra charge. Available medication: compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection.
He & She MD pros
- No membership fee stacked on top of the medication price
- Free expedited shipping on every order, with no shipping upcharges
- Fast 2-3 minute intake with no payment required to check eligibility
- Three formats: semaglutide injection, oral semaglutide, tirzepatide injection
He & She MD cons
- Headline prices are 6-month intro rates that renew 30-45% higher
- Pricing is structured as six-month terms, not true month-to-month
- Compounded GLP-1s are not reviewed by the FDA for safety, efficacy or quality
The cost of choosing this over Directmeds: the headline rates are six-month terms that renew 30-45% higher.
Directmeds or He & She MD: matching the program to the patient
Choose Directmeds if:
- you would get real value from a half-price first month and nationwide shipping with no insurance step
- the level of clinical contact suits you: licensed telehealth prescribing
- you want to start on their timeline: online intake
- delivery works the way you want it to: nationwide shipping, no insurance required
Choose He & She MD if:
- you would get real value from three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO
- you want the full price in front of you before completing an intake
- you want coaching app with 1:1 clinician messaging and progress tracking, no extra charge rather than a prescription alone
- you want tirzepatide available without changing provider later
The trade-offs, stated plainly
On price. Only He & She MD publishes a rate you can plan against (Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo). The other quotes after intake, which is a cost of a different kind: you cannot budget the year in advance.
On clinical contact. The support models differ — licensed telehealth prescribing against coaching app with 1:1 clinician messaging and progress tracking, no extra charge — and that difference is felt in week two, not week one.
On medication. Directmeds covers GLP-1 medication via licensed telehealth prescribing; He & She MD covers compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection. Only He & She MD publishes a tirzepatide route, which matters if semaglutide underdelivers.
On access. Directmeds advertises online intake and nationwide shipping, no insurance required; He & She MD advertises 2-3 minute intake with no payment required to check eligibility and free expedited shipping with no upcharges. Coverage differs too — nationwide against not published — which decides the question before price does if you are in a restricted state.
What the trials and the FDA say
Neither Directmeds nor He & She MD manufactures the molecule it prescribes, and the clinical evidence behind GLP-1 treatment belongs to the drug rather than to any platform selling access to it.
The NIH position is that weight-management medication works alongside changes in eating and activity, not instead of them, per NIH, NIDDK.
Cardiovascular benefit has been demonstrated for semaglutide in a specific population: adults with overweight or obesity and existing cardiovascular disease but no diabetes, per NEJM, SELECT.
Read alongside the pricing above, that is the case for treating the medication decision as clinical and the provider decision as commercial. They are not the same choice.
Directmeds vs He & She MD: common questions
Which is cheaper to start, Directmeds or He & She MD?
Only He & She MD publishes a first-month figure (Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo). The other quotes after intake, so a starting-cost comparison is not available in advance.
How much does Directmeds cost?
Standard post-promotional pricing is not disclosed upfront. That is the honest answer, and it is the main practical drawback next to He & She MD, which publishes Semaglutide from $139/mo, oral semaglutide and tirzepatide from $199/mo upfront. If you go through the intake, ask for the month-two and maintenance-dose prices in writing before paying for the first month.
Can I switch from Directmeds to He & She MD later?
You can, and people do — usually when an introductory price expires. Budget for a repeat intake and a short overlap in supply, and confirm what happens to any unused portion of a multi-month plan before you cancel it.
Is Directmeds or He & She MD better for a first GLP-1 prescription?
First-timers usually get more from clinical access than from a lower rate, because the first two months are where most people stop. On that basis He & She MD has the stronger case; after month three, cost should take over.
Do Directmeds and He & She MD prescribe the same medication?
Both dispense compounded GLP-1 preparations. Directmeds lists GLP-1 medication via licensed telehealth prescribing and He & She MD lists compounded semaglutide injection, oral semaglutide and compounded tirzepatide injection, so the molecules overlap even where the formulary does not match exactly.
Does Directmeds or He & She MD offer tirzepatide?
He & She MD does, at $199/mo. Directmeds publishes GLP-1 medication via licensed telehealth prescribing only, so moving to tirzepatide would mean moving provider — a new intake, a new price, and the loss of any rate you had locked in.
The verdict
Neither of these two publishes enough for a clean cost verdict, which is itself the finding. Directmeds leads on a half-price first month and nationwide shipping with no insurance step; He & She MD leads on three medication formats and a coaching app included, under a named board-certified obesity-medicine CMO.
Before choosing either, get the maintenance-dose price in writing. Without it, any comparison — including this one — is working with half the information.
Whichever way you go, the medication is the same class of drug and the clinical questions belong to a clinician. What you are choosing here is a billing model and a support structure.
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Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Directmeds or He & She MD, and does not sell treatment. Read our ranking methodology.