Tirzepatide access
Yucca Health vs TMates: Which One Offers Tirzepatide? (2026)
Yucca Health $146/mo vs TMates $199/mo. 2026 comparison of pricing, medication and support, with 12-month totals rather than first-month offers.
Published · Pricing as published in our provider dataset, synced · Editorial scores 9.5 and 7.0 out of 10
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Comparing Yucca Health with TMates means comparing two business models more than two medications. The molecules overlap; the terms do not.
Yucca Health will prescribe tirzepatide, the dual GIP/GLP-1 agonist; TMates, on published information, will not. If you already know you want tirzepatide, that decides it before price enters the conversation.
Rather than restate two feature lists, this compares the two on cost over time, medication access, price stability and the support each one includes. Every figure traces back to the provider's own published material, and the missing ones stay missing.
The short answer
- Lowest 12-month cost
- Yucca Health — $1,752 against $2,388 at TMates, on each provider's own best published pricing.
- Most predictable bill
- Yucca Health — Price locked for the life of the plan, so titration does not change what you are charged.
- Tirzepatide access
- Yucca Health — Tirzepatide at $258/mo; the other side publishes semaglutide only.
- Longest public track record
- Yucca Health — 36,958 patient reviews against 21,970.
Yucca Health and TMates, side by side
Two programs, side by side, on their own published terms — with the rows that differ doing the work.
| Yucca Health | TMates | |
|---|---|---|
| Advertised price | Semaglutide $146/mo, tirzepatide $258/mo | $199/mo at every dose, no step-up fees |
| Rate after promotions | $146/mo | $199/mo |
| Pricing structure | Price locked for the life of the plan | Flat rate at every dose |
| Medication | Compounded semaglutide and compounded tirzepatide | Compounded semaglutide |
| Tirzepatide | $258/mo | Not published |
| How fast you start | Approval within 24 hours | Virtual check-in appointments |
| Membership fee | None | None |
| State coverage | All 50 states | All 50 states |
| Support model | No coaching program stated | Provider check-ins included |
| Patient reviews | 36,958 | 21,970 |
| eRxDoctor score | 9.5/10 | 7.0/10 |
Cost over a full course of treatment
A first-month price is a customer-acquisition number. Below, both are carried out to six and twelve months so the comparison holds at the point it matters.
| Yucca Health | TMates | |
|---|---|---|
| First month | $146 | $199 |
| Months 2 onward | $146/mo | $199/mo |
| 6-month total | $876 | $1,194 |
| 12-month total | $1,752 | $2,388 |
| Best published plan | 6-month semaglutide plan at $875 — $1,752/yr | No multi-month discount published |
The twelve-month spread is $636. That is the number to hold TMates against: it has to justify roughly $53 extra every month.
Semaglutide, tirzepatide, and having somewhere to go next
Semaglutide is a GLP-1 receptor agonist. Tirzepatide adds GIP activity, and in head-to-head trial data it has produced larger average weight reductions. That does not make it the right first choice for everyone — it is typically more expensive and the side-effect profile is its own conversation — but it is the usual next step when semaglutide underdelivers.
Yucca Health publishes both, with tirzepatide at $258/mo. TMates publishes compounded semaglutide, so switching molecules would mean switching provider, repeating an intake and losing whatever pricing you had locked in.
If you are confident semaglutide is where you will stay, this difference costs you nothing. If you are not, it is worth more than a small monthly saving.
Yucca Health in detail
Yucca Health (TryYucca) review 2026: personalized compounded semaglutide from $146/month and tirzepatide from $258/month. Fast 24-hr approval, UPS 2-Day Air, Klarna/Affirm/Afterpay accepted. In this pairing, its distinguishing feature is a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market.
The process is approval within 24 hours, then UPS 2-Day Air from a licensed U.S. compounding pharmacy. On money, expect price locked for the life of the plan — published upfront.
Behind the prescription sits personalized treatment plans from board-certified providers. Available medication: compounded semaglutide and compounded tirzepatide.
Yucca Health pros
- Three Buy Now Pay Later options: Klarna, Afterpay, and Affirm
- 6-month semaglutide plan at $875 locks in the best per-month rate
- Compounded tirzepatide from $258/month, dual GIP/GLP-1 mechanism for higher average weight loss
- Compounded semaglutide from $146/month, one of the lowest prices from a legitimate GLP-1 telehealth provider
Yucca Health cons
- No weight loss warranty or outcome guarantee
- Cancellation terms for multi-month plans should be confirmed before purchase
- No branded FDA-approved medications (Ozempic, Wegovy, Zepbound)
Set beside TMates, the thing to weigh: no branded medication, no insurance billing and no outcome guarantee.
A closer look at TMates
$199/month, every dose, no step-up fees What it is really selling here is one flat $199 that survives every titration step, with doctors rather than a message queue behind it.
You start with virtual check-in appointments; medication arrives via medication formulated in U.S. facilities. The price behaves as flat rate at every dose.
Ongoing care is 24/7 access to U.S.-based doctors, not just messaging, and the medication list runs to compounded semaglutide.
TMates pros
- Licensed coverage in all 50 states
- Medications formulated in U.S.-based facilities
- Flat $199/month at every dose, no step-up fees as dosage escalates
- 24/7 access to U.S.-based doctors, not just messaging support
TMates cons
- No branded Ozempic, Wegovy, or Zepbound
- Compounded semaglutide only, limited public detail on tirzepatide availability
- $199/month is higher than the cheapest compounded options
Against Yucca Health specifically, the trade you are making: semaglutide only, and $199 is well above the cheapest compounded options.
Who each program is actually built for
Choose Yucca Health if:
- delivery works the way you want it to: UPS 2-Day Air from a licensed U.S. compounding pharmacy
- you want to start on their timeline: approval within 24 hours
- the level of clinical contact suits you: personalized treatment plans from board-certified providers
- you would get real value from a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market
Choose TMates if:
- you want to start on their timeline: virtual check-in appointments
- the level of clinical contact suits you: 24/7 access to U.S.-based doctors, not just messaging
- the feature you would actually use: one flat $199 that survives every titration step, with doctors rather than a message queue behind it
- you want the price you sign up at to survive titration
The compromises on both sides
On price. Yucca Health is the cheaper program at $146/mo against $199/mo. What Yucca Health gives up for that is no branded medication, no insurance billing and no outcome guarantee; what TMates charges for is one flat $199 that survives every titration step, with doctors rather than a message queue behind it.
On commitment. Yucca Health rewards a longer commitment (6-month semaglutide plan at $875), which lowers the effective rate but ties up money before you know how you respond to the medication. Financing is available through Yucca Health (Klarna, Afterpay and Affirm).
On medication. Yucca Health covers compounded semaglutide and compounded tirzepatide; TMates covers compounded semaglutide. Only Yucca Health publishes a tirzepatide route, which matters if semaglutide underdelivers.
On clinical contact. Personalized treatment plans from board-certified providers at Yucca Health; 24/7 access to U.S.-based doctors, not just messaging at TMates. Neither is a substitute for in-person care if you have complicating conditions, and both bill you directly rather than your insurer.
What the trials and the FDA say
The efficacy data people cite when comparing these platforms is not platform data. It comes from trials of the underlying medication, and it applies to both.
NIDDK frames medication as one component of obesity treatment rather than a replacement for the rest of it, per NIH, NIDDK.
The STEP 1 extension found participants regained roughly two-thirds of the weight they had lost within a year of stopping semaglutide, per Diabetes, Obesity and Metabolism.
Use it as the floor for the conversation with whichever prescriber you end up with, rather than as a reason to pick one platform over the other.
Yucca Health vs TMates: common questions
Which is cheaper to start, Yucca Health or TMates?
Yucca Health, at $146 against $199. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
How fast can I start with Yucca Health compared with TMates?
Yucca Health advertises approval within 24 hours, with UPS 2-Day Air from a licensed U.S. compounding pharmacy. TMates advertises virtual check-in appointments, with medication formulated in U.S. facilities. Both are subject to clinician review and to whether your state and health history clear, so treat the advertised timeline as a best case rather than a commitment.
Are Yucca Health and TMates legitimate?
Both are licensed telehealth platforms that route a prescription through a clinician review before anything is dispensed; neither sells medication without one. Yucca Health operates on price locked for the life of the plan with pricing published upfront, TMates on flat rate at every dose, published upfront. The meaningful due diligence is on the medication category and the terms, not on whether the platforms are real.
What happens if I stop taking the medication?
Both programs are month to month, which makes stopping easy and makes the consequence of stopping the thing to plan for: published extension data shows most of the lost weight returns within about a year. That is an argument for choosing on annual cost rather than entry price.
Is Yucca Health or TMates better for a first GLP-1 prescription?
If this is your first GLP-1, the question is who answers when nausea arrives on day nine. TMates publishes 24/7 access to U.S.-based doctors, not just messaging, which is the more useful thing to buy at the start.
Can I switch from Yucca Health to TMates later?
Yes. Neither program locks you in clinically, and both operate month to month unless you have bought a multi-month plan. Practically, switching means a fresh intake, a fresh clinician review and possibly a gap in supply, so time it against your current shipment rather than your renewal date, and check the refund terms on any prepaid plan first.
Does Yucca Health or TMates offer tirzepatide?
Yucca Health does, at $258/mo. TMates publishes compounded semaglutide only, so moving to tirzepatide would mean moving provider — a new intake, a new price, and the loss of any rate you had locked in.
The verdict
Yucca Health is the cheaper year by $636, and for a straightforward course of treatment that settles it.
TMates earns the difference in one situation: when one flat $199 that survives every titration step, with doctors rather than a message queue behind it is something you will genuinely use. If you cannot say that out loud, take the cheaper program.
Get the maintenance-dose price in writing from whichever one you pick. That single question prevents most of the regret in this category.
Keep comparing
- Yucca Health vs Mochi HealthLocked price vs escalating price
- Yucca Health vs Elevate HealthFinancing and HSA/FSA
- Wellmedr vs TMatesBudget vs premium
- TrimRx vs TMatesTirzepatide access
- Refills vs MaximusTirzepatide access
- Gala vs Start WillowTirzepatide access
See every provider in context on the weight loss rankings, or browse the full comparison index.
Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by Yucca Health or TMates, and does not sell treatment. Read our ranking methodology.