Same price, different service model
TrimRx vs Yucca Health: Same Price, Different Deal (2026)
TrimRx $149/mo vs Yucca Health $146/mo. 2026 comparison of pricing, medication and support, with 12-month totals rather than first-month offers.
Published · Pricing as published in our provider dataset, synced · Editorial scores 9.7 and 9.5 out of 10
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On paper, TrimRx and Yucca Health sell the same thing: a prescription, a vial and a delivery date. In practice they are priced and staffed on different assumptions.
Within a few dollars, these two charge the same monthly rate. The comparison is therefore entirely about service model: what TrimRx bundles that Yucca Health does not, and vice versa.
Rather than restate two feature lists, this compares the two on cost over time, medication access, price stability and the support each one includes. Where a provider quotes only after intake, that is recorded as the answer rather than replaced with a guess.
The short answer
- Lowest 12-month cost
- Yucca Health — $1,752 against $1,788 at TrimRx, on each provider's own best published pricing.
- Most predictable bill
- TrimRx — Price locked for the life of the plan, so titration does not change what you are charged.
- Quickest to start
- Yucca Health — Approval within 24 hours, then UPS 2-Day Air from a licensed U.S. compounding pharmacy.
- Longest public track record
- Yucca Health — 36,958 patient reviews against 18,420.
TrimRx vs Yucca Health: the specification
Two programs, side by side, on their own published terms — with the rows that differ doing the work.
| TrimRx | Yucca Health | |
|---|---|---|
| Advertised price | GLP-1 from $149/mo, GLP-1+GIP from $249/mo | Semaglutide $146/mo, tirzepatide $258/mo |
| Rate after promotions | $149/mo | $146/mo |
| Pricing structure | Price locked for the life of the plan | Price locked for the life of the plan |
| Medication | Compounded semaglutide and compounded tirzepatide (GLP-1+GIP) | Compounded semaglutide and compounded tirzepatide |
| Membership fee | None | None |
| Payment options | HSA/FSA, Affirm, Klarna and Afterpay | Klarna, Afterpay and Affirm |
| State coverage | Not published | All 50 states |
| How fast you start | Online intake, no clinic visit | Approval within 24 hours |
| Patient reviews | 18,420 | 36,958 |
| eRxDoctor score | 9.7/10 | 9.5/10 |
TrimRx vs Yucca Health on total cost, not entry price
A first-month price is a customer-acquisition number. The totals below are the honest version, built from the rates each provider publishes.
| TrimRx | Yucca Health | |
|---|---|---|
| First month | $149 | $146 |
| Months 2 onward | $149/mo | $146/mo |
| 6-month total | $894 | $876 |
| 12-month total | $1,788 | $1,752 |
| Best published plan | No multi-month discount published | 6-month semaglutide plan at $875 — $1,752/yr |
Yucca Health finishes the year $36 cheaper. For some patients the support TrimRx bundles closes that gap; for a patient who only needs the prescription written, it does not.
Same money, different program
At $149/mo and $146/mo, price is a wash. So the comparison moves to what each one does with the money: TrimRx puts it into Lifetime Price Protection, so the number you sign up at is the number you pay at every dose, while Yucca Health puts it into a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market.
The structures differ underneath the matching numbers, too — price locked for the life of the plan at TrimRx against price locked for the life of the plan at Yucca Health. That is what decides which of the two identical-looking prices is still identical in month six.
When price ties, pick on the failure mode you most want covered: the one that answers fastest when something goes wrong, or the one that keeps the medication you might want to switch to on its own formulary.
TrimRx in detail
TrimRx: 100k+ happy customers, 4.8 Excellent Rating. Compounded GLP-1 from $149/month and GLP-1+GIP from $249/month with Lifetime Price Protection, free 1–2 day shipping, 24/7 support, HSA/FSA eligible.
From signup to first shipment: online intake, no clinic visit, then free shipping, arrives in 1-2 days. Billing follows a price locked for the life of the plan structure.
What continues after the first shipment: unlimited 24/7 specialist access, appointments and messaging. Formulary: compounded semaglutide and compounded tirzepatide (GLP-1+GIP).
TrimRx pros
- Cancel anytime
- No insurance required, no monthly membership, no hidden fees
- Lifetime Price Protection: lock in today's price for life — same price, every dose
- Both GLP-1 (semaglutide) starting at $149/month and GLP-1+GIP (tirzepatide) starting at $249/month available
TrimRx cons
- Direct-pay model, insurance is not billed
- Compounded medication only, no branded Ozempic, Wegovy, or Zepbound
- GLP-1+GIP option at $249/month is higher than GLP-1-only entry price
Set beside Yucca Health, the thing to weigh: compounded medication only, and insurance is never billed.
A closer look at Yucca Health
The pitch is a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market. Yucca Health (TryYucca) review 2026: personalized compounded semaglutide from $146/month and tirzepatide from $258/month. Fast 24-hr approval, UPS 2-Day Air, Klarna/Affirm/Afterpay accepted.
Practically: approval within 24 hours, UPS 2-Day Air from a licensed U.S. compounding pharmacy, and a pricing model that is price locked for the life of the plan.
On the clinical side, personalized treatment plans from board-certified providers, prescribing compounded semaglutide and compounded tirzepatide.
Yucca Health pros
- 6-month semaglutide plan at $875 locks in the best per-month rate
- Three Buy Now Pay Later options: Klarna, Afterpay, and Affirm
- Compounded semaglutide from $146/month, one of the lowest prices from a legitimate GLP-1 telehealth provider
- Compounded tirzepatide from $258/month, dual GIP/GLP-1 mechanism for higher average weight loss
Yucca Health cons
- Cancellation terms for multi-month plans should be confirmed before purchase
- No weight loss warranty or outcome guarantee
- Does not accept health insurance
Against TrimRx specifically, the trade you are making: no branded medication, no insurance billing and no outcome guarantee.
Who should choose TrimRx, and who should choose Yucca Health
Choose TrimRx if:
- you want to start on their timeline: online intake, no clinic visit
- the level of clinical contact suits you: unlimited 24/7 specialist access, appointments and messaging
- what it leads on is worth paying for in your case: Lifetime Price Protection, so the number you sign up at is the number you pay at every dose
- you want the price you sign up at to survive titration
Choose Yucca Health if:
- you want to start on their timeline: approval within 24 hours
- the level of clinical contact suits you: personalized treatment plans from board-certified providers
- the feature you would actually use: a price lock at $146 plus three buy-now-pay-later options, which is unusual at the bottom of the market
- the twelve-month total is what you are optimizing ($1,752 against $1,788)
The trade-offs, stated plainly
On price. The monthly gap is 2% in Yucca Health's favor. Whether that is a saving or a false economy turns on one thing: no branded medication, no insurance billing and no outcome guarantee.
On commitment. Yucca Health rewards a longer commitment (6-month semaglutide plan at $875), which lowers the effective rate but ties up money before you know how you respond to the medication. Financing is available through TrimRx (HSA/FSA, Affirm, Klarna and Afterpay) and Yucca Health (Klarna, Afterpay and Affirm).
On medication. TrimRx covers compounded semaglutide and compounded tirzepatide (GLP-1+GIP); Yucca Health covers compounded semaglutide and compounded tirzepatide. Neither locks you out of a molecule the other offers, so this is unlikely to be the deciding factor.
On clinical contact. Unlimited 24/7 specialist access, appointments and messaging at TrimRx; personalized treatment plans from board-certified providers at Yucca Health. Neither is a substitute for in-person care if you have complicating conditions, and both bill you directly rather than your insurer.
What the trials and the FDA say
Weight loss percentages quoted in telehealth marketing come from trials neither TrimRx nor Yucca Health ran. Here is the source material, and what regulators say alongside it.
NIDDK frames medication as one component of obesity treatment rather than a replacement for the rest of it, per NIH, NIDDK.
SURMOUNT-4 found that continuing tirzepatide maintained and extended weight reduction, while withdrawing it led to substantial regain, per JAMA, SURMOUNT-4.
Use it as the floor for the conversation with whichever prescriber you end up with, rather than as a reason to pick one platform over the other.
TrimRx vs Yucca Health: common questions
Which is cheaper to start, TrimRx or Yucca Health?
Yucca Health, at $146 against $149. Note that the cheapest first month and the cheapest year are often different providers here — check the 12-month row of the cost table before deciding on the entry price.
Which costs less over a year, TrimRx or Yucca Health?
Yucca Health, at roughly $1,752 for twelve months against $1,788 at TrimRx, using each provider's own best published pricing. Those totals cover medication and program fees as published; they exclude anything a provider bills separately, and they assume you stay on the same plan for the full year.
Are TrimRx and Yucca Health legitimate?
Both are licensed telehealth platforms that route a prescription through a clinician review before anything is dispensed; neither sells medication without one. TrimRx operates on price locked for the life of the plan with pricing published upfront, Yucca Health on price locked for the life of the plan, published upfront. The meaningful due diligence is on the medication category and the terms, not on whether the platforms are real.
What happens if I stop taking the medication?
Both programs are month to month, which makes stopping easy and makes the consequence of stopping the thing to plan for: published extension data shows most of the lost weight returns within about a year. That is an argument for choosing on annual cost rather than entry price.
Is TrimRx or Yucca Health better for a first GLP-1 prescription?
First-timers usually get more from clinical access than from a lower rate, because the first two months are where most people stop. On that basis TrimRx has the stronger case; after month three, cost should take over.
Can I switch from TrimRx to Yucca Health later?
Yes. Neither program locks you in clinically, and both operate month to month unless you have bought a multi-month plan. Practically, switching means a fresh intake, a fresh clinician review and possibly a gap in supply, so time it against your current shipment rather than your renewal date, and check the refund terms on any prepaid plan first.
Do TrimRx and Yucca Health prescribe the same medication?
Both dispense compounded GLP-1 preparations. TrimRx lists compounded semaglutide and compounded tirzepatide (GLP-1+GIP) and Yucca Health lists compounded semaglutide and compounded tirzepatide, so the molecules overlap even where the formulary does not match exactly.
The verdict
On the numbers, Yucca Health wins the year: $1,752 against $1,788. That is the default answer, and it is the right one for anyone who mainly needs a reliable prescription and a shipment that arrives.
The case for TrimRx is Lifetime Price Protection, so the number you sign up at is the number you pay at every dose. That is worth $3 a month to some patients and nothing at all to others — be honest about which you are.
Get the maintenance-dose price in writing from whichever one you pick. That single question prevents most of the regret in this category.
Keep comparing
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- TrimRx vs NoviFinancing and HSA/FSA
- Yucca Health vs MaximusTirzepatide access
- Yucca Health vs He & She MDLocked price vs escalating price
- Gala vs Sprout HealthSame price, different service model
- Novi vs Elevate HealthSame price, different service model
See every provider in context on the weight loss rankings, or browse the full comparison index.
Disclaimers and methodology
Medical content is informational only and does not replace professional diagnosis, treatment, or emergency care.
Some links are affiliate links and may generate commission at no extra cost to you.
Pricing reflects what each provider published as of the sync date above and changes frequently; confirm the current rate, and the rate at your maintenance dose, before you pay. Six- and twelve-month totals are calculated from those published rates and exclude anything a provider bills separately.
eRxDoctor is an independent publisher. It is not a medical provider, is not affiliated with or endorsed by TrimRx or Yucca Health, and does not sell treatment. Read our ranking methodology.